Cells tightly regulate concentrations of purine nucleotides because they have important roles in cell proliferation, as components of synthesis of RNA and DNA, and in other cellular metabolic and signaling functions. Purines can be produced by de …
Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands. Chemical proteomics has …