Proteomics

Cells tightly regulate concentrations of purine nucleotides because they have important roles in cell proliferation, as components of synthesis of RNA and DNA, and in other cellular metabolic and signaling functions. Purines can be produced by de …

Role of hijacked host cellular proteins in immune escape mechanisms of SARS-CoV-2

Novel immune escape mechanism of severe coronavirus disease 2019 (COVID-19)

SARS-CoV-2 reproducibly incorporates a subset of host cellular proteins, including complement regulators into its virions

Data -processing, -analysis and -management pipeline for high thrroughput screening in the context of fragment based ligand discovery

Overview of the informatics tools and techniques we built for 2024 Science paper

Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands. Chemical proteomics has …

β15-42 acts as a gatekeeper of thrombus resolution and is a potential therapeutic target.

In every fifth human cancer, a mutation is found in one of the BAF complex genes because they control accessibility of the DNA

Large Scale Fragment based Ligand Discovery using DDA and TMT