Modern mass spectrometric approaches enable us to characterizes lipidomes consisting hundreds of molecular species. In this context several initiatives have delivered insights into the developmental and tissue specificity of lipidomes. Depending on their biosynthetic ability drosophila, C. elegans, yeast and mammals exhibit membrane systems which can fulfil the functional requirements to act as neuronal, epithelial or secretory tissue. These widely accepted model organisms exhibit unique molecuar species in their lipidomes which cannot be addressed from a perspective of changing quantities of shared molecules. To utilize the systematic analysis of biological models for our understanding of cellular mebrane organization and lipid homeostasis we developed a metrics system which can help in analogy to proteome, transcriptome and genome analysis to define motifs and domains in a lipidome. To this end, we suggest an informatic method to determine the homolgy between lipidomes.