Lipids play major role in human health and disease. To understand their function, model organisms like D.melanogaster, S. cervisiae, C. elegans etc. are commonly employed. However, it is known that lipid structures in these model organisms are different from humans. To extrapolate the functional implications of model organism’s lipidome to humans, a criterion is necessary. We hypothesized that lipid structures and their structural relation to each constituent of a given lipidome might be the best link to function. Lipidome Juxtaposition Score (LUX Score) describes the-overall-structural-differences between lipids of any given pair of cells/tissues or organisms. We develop the LUX Score with the aim to provide a tool that facilitates systems biology research